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Thus, future research will require multi-center, large-scale randomized controlled trials to validate the feasibility and effectiveness of these drugs in clinical settings

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Although newer medications like crisaborole and dupilumab have shown effectiveness in treating AD, their high cost makes them inaccessible to most patients at present (211, 212)

Dynamic compartmentalization across organelles such as the nucleus, endoplasmic reticulum (ER), mitochondria, Golgi apparatus, lysosomes, endosomes and peroxisomes is a requirement for the effective regulation of zinc